Product Details
Fusi-Zon (2% Fusidic Acid/1% Hydrocortisone Acetate) Combines The Antibacterial Activity Of Fusidic Acid With The Anti-Inflammatory Activity Of The Mild Potency Corticosteroid Hydrocortisone Acetate.
The Antibacterial Action Of Fusidic Acid Results From Inhibition Of Bacterial Protein Synthesis. The Drug Interferes With Amino Acid Transfer From Aminoacyl-Trna To Protein On The Ribosomes. The Spectrum Of Antibacterial Activity Of Fusidic Acid Is Primarily Toward Gram Positive Organisms, Demonstrating Particularly High Activity Against Staph. Aureus. Hydrocortisone Acetate Has Anti-Inflammatory, Antipruritic, And Vasoconstrictive Properties. The Mechanism Of The Anti-Inflammatory Activity Of Topical Corticosteroids Is Generally Unclear. However, Corticosteroids Are Thought To Induce Phospholipase A2 Inhibitor Proteins, Preventing Arachidonic Acid Release And The Biosynthesis Of Potent Mediators Of Inflammation.
Skin Penetration By Fusidic Acid Is Comparable To That Of Glucocorticoids. As Much As 2% Of The Amount Of Topically Applied Fusidic Acid Penetrates Intact Skin. Dermal Absorption Of Hydrocortisone Is Considered To Be Approximately 1-5% Of The Administered Dose. Absorption Of Hydrocortisone May Be Higher In Certain Body Areas Such As The Face, Groin, Axilla, Or On Injured Or Inflamed Skin Such As The Lesions Of Atopic Dermatitis.
The Efficacy Of Fusi-Zon In The Treatment Of Mild To Moderately Severe Atopic Dermatitis Has Been Compared With That Of Its’ Individual Components, Fusidic Acid And Hydrocortisone In Clinical Studies. For Patients With Staph. Aureus Present On The Lesions, Fusi-Zon Was More Effective Than Either Hydrocortisone Or Fucidic Acid Based On A Single Efficacy Criterion For Alleviation Of Classical Symptoms (Erythema, Scaling, Oedema, Itch, Serous Discharge, And Crusting) And Bacteriological Eradication At Completion Of 14 Days Of Treatment. There Is No Data Available Regarding Relapse Rate.
